Relationship between ischemia modified albumin (IMA) in Different Age Groups and Gender Variance

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Abstract

The purpose of the study was to find the relationship between ischemia modified albumin (IMA) in different age groups and gender variance.IMA has been found to be present in high levels in cardiac ischemic patients. Many studies have been done on the relationship of other biomarkers such as troponin to gender and different age groups (Rodriguez-Ospina, 331; Wiviott et al, 1415).Therefore, further research need to be done to find out whether there exist differences in the levels of IMA between different age groups, and also in gender. The results of the study will be helpful in correct diagnosis of cardiac ischemia among patients, in addition to stratification of the patients that suffer from acute chest pains. Correct diagnosis means immediate treatment and management of the cardiac ischemia before it destroys the myocytes.

Introduction

Cardiac bio makers According to Rodriguez-Ospina et al (14) are substances released by the heart into the blood stream when it is stressed or damaged. Measurement of the released bio makers in the blood stream is helpful in diagnosis, monitoring, risk stratification and in management of people suspected to have cardiac ischemia and acute coronary syndrome (ACS). Cardiac ischemia results when blood supply that goes to the tissues of the heart is not enough to meet the needs of the heart. This results in a sudden blood decrease and oxygen that reaches the heart. Tousoulis et al (15) highlighted some of the different types of cardiac biomarkers tests but the most used and effective one is the troponin test. However, cardiac troponin is only specific and sensitive for detection of damage in myocardium, but sometimes may not rise in there is reversible myocardial ischemia. Further research is needed to clarify whether pathophysiological differences that are gender related exist in acute coronary syndromes presentation. The aim of the study was to find out the levels of IMA in different age groups and gender variance

Methods

Ninety six patients with acute chest pain between age group 30-60years admitted in ICCU of hospital participated in the study. Among these subjects, 40 were male and 56 were female.  Of the 96 patients, 16 of them had no evidence of myocardial ischemia. They were categorized as group II. The remaining 80 patients with evidence of myocardial ischemia were categorized into group I. About 41% of the patients of group I was between 50-60 years of age. The control group of healthy subjects was 28, of which 10 were males and 18 females.

Patients were evaluated as being non ischemic or potentially ischemic through standard coronary disease indicators [(CK), CK-MB, LDH and electrocardiography findings and were tested by a Co (II)-albumin binding assay for IMA. The patients of ischemic group (group 1) were further divided in to three groups based on their age &sex as follows; 30-40 years (M&F), 40-50 years (M&F), and 50-60 years (M&F).

 

Results

Table: Age wise distribution of cardiac markers in Ischemic group     

 

 

Age 30-40yrs 40-50yrs 50-60yrs
Sex Males (n=11) Females (n=13) Males (n=9) Females (n=14) Males (n=14) Females (n=19)
CK (IU/l)

Mean ± SD

102±18.0 80±22.0 96±28.0 94±26.0 115±48.0 124±36.0
CK-MB (IU/l)

Mean ± SD

10±1.26

Type: Essay || Words: 2011 Rating || Excellent

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