Histology Detective

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Histology Detective and Brains Cape

Histology Detective and Brains Cape

  • This case study focuses on the identification of metastatic tissues — cells that are “out of place” causing tumors elsewhere in the Name the cells you identified in this sample of lung tissue and the main characteristics that you can use to distinguish them.

From the observation of the sample, there are a variety of cells that can be identified as melanocytes. The main characteristics that can be used in distinguishing them are their attachment to the stratified squamous epithelial tissue. Moreover, they are larger and darker compared to the surrounding calls. Melanocytes are densely packed and have only one nucleus.

  • How did you use the main characteristics of different tissues that you learned in your lecture and lab sections as the basis for identifying those cells responsible for the tumor?

I applied my histology knowledge from my lectures in distinguishing the features of different cells. I knew how melanocytes and the natural cells look like on a slide hence it was very easy to distinguishing and describing the cells. The cells under observations were abnormal from their look. They were larger in size, darker in color, and round. Moreover. Their nucleus was larger compared to the other nucleus of the normal cells and has less cytoplasm. The melanocytes on the slide are always darker compared to the normal cells. According to Garbe et al (2010), there exist significant differences between the tumor cells and the native cells since the tumor cells are widespread in the extracellular fluid, are larger, much darker, and more so cube-shaped. On the other hand, the native cells are packed densely, smaller, and elongated.

  • In addition to the information in the case presentation (including the web sites contained in the case itself), what other information did you find to determine the identity of the cells and whether one type of cell had migrated from elsewhere in the body? Where did you find this information?
  1. Garbe, C., Peris, K., Hauschild, A., Saiga, P., Middleton, M., Spatz, A., Grob, J. J., … Eggermont, A. (January 01, 2010). Diagnosis and treatment of melanoma: European consensus-based interdisciplinary guideline. European Journal of Cancer, 46, 2, 270-283. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/19959353
  2. NIH Consensus Development Conference on

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