Histology Detective and Brains Cape

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  • This case study focuses on the identification of metastatic tissues — cells that are “out of place” causing tumors elsewhere in the Name the cells you identified in this sample of lung tissue and the main characteristics that you can use to distinguish them.

From the observation of the sample there are variety of cells which can be identified as melanocytes. The main characteristics that can be used in distinguishing them is their attachment to the stratified squamous epithelial tissue. Moreover, they are larger and darker compared to the surrounding calls. Melanocytes are densely packed and have only one nucleus.

  • How did you use the main characteristics of different tissues that you learned in your lecture and lab sections as the basis for identifying those cells responsible for the tumor?

I applied my histology knowledge from my lectures in distinguishing the features of different cells. I had knowledge on how melanocytes and the natural cells look like on a slide hence it was very easy distinguishing and describing the cells. The cells under observations were abnormal from their look. They were larger in size, darker in color and round. Moreover. Their nucleus were larger compared to the other nucleus of the normal cells and has less cytoplasm. The melanocytes on the slide is always darker compared to the normal cells. According to Garbe et al (2010), there exists significant differences between the tumor cells and the native cells since the tumor cells are widespread in the extracellular fluid, are larger, much darker and more so cube shaped. On the other hand, the native cells are packed densely, smaller, and elongated.

  • In addition to the information in the case presentation (including the web sites contained in the case itself), what other information did you find to determine the identity of the cells and whether one type of cell had migrated from elsewhere in the body? Where did you find this information?
  1. Garbe, C., Peris, K., Hauschild, A., Saiag, P., Middleton, M., Spatz, A., Grob, J. J., … Eggermont, A. (January 01, 2010). Diagnosis and treatment of melanoma: European consensus-based interdisciplinary guideline. European Journal of Cancer, 46, 2, 270-283. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/19959353
  2. NIH Consensus Development Conference on Diagnosis and Treatment of Early Melanoma, & National Institutes of Health (U.S.). (1992). Diagnosis and treatment of early melanoma. Bethesda, Md: U.S. Dept. of Health and Human Services, National Institutes of Health, Public Health Service, Office of Medical Applications of Research. Retrieved from http://consensus.nih.gov/1992/1992Melanoma088html.htm
  3. Sonda, Vemon K., MD, Zager, Jonathan S., MD, Messiana, Jane L., M Hemonc today. (2008, Oct 10). Retrieved from http://www.hemonctoday.com/article.aspx?rid=37772

 What does each of these additional items contribute to the solution of the case? For example, the.............


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