Probation Reflection Paper

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Paper instructions:i
You are required to complete a reflection paper that will represent your observations of the readings, a critical evaluation of the topic, and thoughts on how best

to address the problems/issues inherent in the topic you have chosen to write about.

You must utilize a minimum of four outside sources to inform your paper. (Should you choose to cite your text or articles assigned for the course, you may do so

but these citations will be in addition to the four outside sources you must locate on your topic). These sources must be peer-reviewed publication or governmental

reports.

Your paper must be a minimum of 7 pages in length (does not include front matter or references and other back matter), maximum 12-point , 1-inch margins, include

your name, and utilize proper APA citation format.

Organize the paper as follow:

Identify the topic and provide an overview of the issue, its relationship to corrections, and how this topic is currently handled/addressed in corrections

policy/practice (you may provide ‘real time’ examples from correctional jurisdictions if this will help you make your point). This section of the paper should be

approximately 2-1/2 pages in length.

Provide a critical evaluation of this topic including information that supports and/or disputes current policy and practice. This section of the paper should be

approximately 2-1/2 page in length.

Provide thoughts on how best to improve/address the problems/issues inherent in the topic, including providing an example of ‘best practices’ (if they exist). This

section of the paper should be approximately 2 pages in length.

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Probation Reflection Paper 1

. Tell us about a time within the past three years when you had to give difficult feedback to a peer

seo-automated-link-building-1Riftcom, a company that roots its operations in the telecommunication industry, based strategically in the regional market had agreed unanimously on a new program that would soon hit the market. The program was for designing a system that monitors online money transfers from an individual to individuals or group or companies. As a tradition of the company, my team was tasked to conduct the feasibility study of the product on the responsiveness of the market towards any product developed within the company. The day of handing over and presentation of my feasibility study report was on 11th October 2013 and from my findings and recommendations, I believed the feedback to the management will be very hard to be accepted or even to convince them.
On that material day, we all gathered in the members’ boardroom, and I did bit by bit of the report presentation. Every information captured on power point presentation. Due to the nature of the program I ensured necessary, and relevant information passed across to the present members who tirelessly developed the system knowing that would have risen the horizons of the company.
I continuously and repetitively went through the same presentation to convince the management that proceeding with the launch and implementation of the system of the product was a decision that will eat into the company’s reputation. Riftcom Company already enjoyed a chunk of the market and forcing a product of such sensitivity that deals with monitoring money transfers would negate the gains we all endured to see a move to the next horizon.
Questions began flowing fast and thick from the panel and members in general. The concerns ranged from the methodologies employed in data analysis of our feasibility studies. I had to keep referring to previous slides to remind everyone on the boardroom that every aspect was done above board. From the body language, I could tell how much disappointed the executive were bearing in mind the cost the company had incurred.
I explained to the management board that we did prospects of the success of the product. I as a program/project manager, I headed the team, and all presentations were bestowed on me. Therefore, due to competitive market we were operating on, objectivity was an important factor that I had to emphasize to the team as usual. From the onset, going through the majority of our collections and surveys the product was negative in terms of responsiveness to the market. Riftcom Company had invested intensively in the system that our report would be a no-no to the executive.
Therefore, a unanimous decision after my presentation was adopted to postpone the entire product of a system and probably work on a modified system. The recommendations that the management wanted considered on the next product could tell the weighty aspect of the feedback we delivered.

 

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. Tell us about a time within the past three years when you had to give difficult feedback to a peer 2

The Clinical Trials

seo-automated-link-building-1Clinical Trials
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Course:
Instructor’s Name:
Date:

The relevance of preclinical studies to the development of clinical trials in humans Resources
Clinical research is a process that is rigorous of testing the efficacy and safety of candidate vaccines, therapies and diagnostics. Only the candidates that have exceptionally performed through basic and pre-clinical research get approval for clinical trials in human beings. The essay will discuss the relevance of preclinical studies to the development of clinical trials in human resources (Field & Boat, 2010).
Once a single compounding that is promising has been selected based on therapeutic discovery and basic research, pharmacological companies start the pre-clinical studies both in animals and in vitro to evaluate the potential toxicity and drug safety. These pre-clinical studies are also applied in assessing the potential effectiveness (Glaser, 2015)
Pre-clinical studies are also relevant to the development of clinical trials in human resources because the data and safety from the pre-clinical studies are vital in determining whether a drug will progress on to studies in the human bodies. Moreover, pre-clinical studies also offer guidance to the researcher in designing phase one of the clinical trials. For instance, pre-clinical studies with the animal assist in determining the range of giving dosages of a test a drug for evaluation in phase one clinical trial (Field & Boat, 2010).
Pre-clinical studies are also relevant in that they help in identifying evaluation criteria for human safety, including signs and symptoms that should be closely monitored during the early stages of clinical trials (Glaser, 2015).
According to Field & Boat (2010), pre-clinical studies also generate pharmacological profile of a drug under study that will be of significance long into the future of the drug. For instance, the researcher can use the drug profile from pre-clinical studies in developing the initial process of manufacturing and pharmaceutical formulation for use in human testing.
Genotype-Tissue Expression (GTEx)
The Genotype-Tissue Expression (GTEx) program is pursued by NIH with an aim of studying expression and regulation of the human gene in multiple tissues, providing insights that are valuable into the gene regulation mechanisms, and in the future perturbations that are diseases related (NIH, 2015).
The 2013 peer reviewed article by GTEx Consortium addresses the program of Genotype-Tissue Expression (GTEx) in detail (GTEx Consortium, 2013). Moreover, there are other sources of information about this project available on the online newspaper articles and the internet such as the NIH Genotype-Tissue Expression (GTEx) brochure (NIH, 2015).
The Genotype-Tissue Expression (GTEx) program has several initiatives that NIH is pursuing with the purpose of enhancing both clinical research nationally and the program. Some of the initiatives include:
1. Novel Statistical Methods for Human Gene Expression Quantitative Trait Loci (eQTL) Analysis
This initiative solicits applications for developing statistical methods that are innovative in detecting genetic variation influence on tissue-specific gene regulation and expression. The goal of the initiative was to seek proposals of developing statistical methods to analyze appropriately the forthcoming complex set of data generated by the roadmap initiative of NIH entitled The Genotype-Tissue Expression (GTEx) project (Federal Grants, 2015). This initiative will influence the clinical trial stage of omics data and bio specimens where there would collection of normal bio specimens for the GTEx.

2. Laboratory, Data Analysis, and Coordinating Center (LDACC)
This initiative was established to seek small business which has the capability of serving as laboratory, data analysis and center for coordination for their new pilot program of The Genotype-Tissue Expression (GTEx) (FBO, 2008). This initiative will be influence the GTEx Pilot Phase Data when analyzing and to Show How Differences in DNA Affect Disease Susceptibility and Gene Activity.

References
Federal Business Opportunities,. (2008). Laboratory, Data Analysis, and Coordinating Center (LDACC) – Federal Business Opportunities: Opportunities. Fbo.gov. Retrieved 25 May 2015, from https://www.fbo.gov/index?s=opportunity&mode=form&id=460c8226b5e734ef33a8f4aeb8a645a6&tab=core&_cview=0
Federal Grants,. (2015). Novel statistical methods for human gene expression quantitative trait loci eQTL analysis R01 – Federal Grant. Federalgrants.com. Retrieved 25 May 2015, from http://www.federalgrants.com/Novel-statistical-methods-for-human-gene-expression-quantitative-trait-loci-eQTL-analysis-R01-18028.html
Field, M., & Boat, T. (2010). Development of New Therapeutic Drugs and Biologics for Rare Diseases. National Academies Press (US). Retrieved from http://www.ncbi.nlm.nih.gov/books/NBK56179/
Glaser, V. (2015). Building Better Pipelines with ADME-Tox | GEN Magazine Articles | GEN. GEN. Retrieved 25 May 2015, from http://www.genengnews.com/gen-articles/building-better-pipelines-with-adme-tox/2111/
GTEx Consortium. (January 01, 2013). The Genotype-Tissue Expression (GTEx) project. Nature Genetics, 45, 6, 580-5.
NIH,. (2015). Genotype-Tissue Expression (GTEx) program. NIH. Retrieved 25 May 2015, from http://commonfund.nih.gov/sites/default/files/GTEx_trifold_final_2012.pdf
NIH,. (2015). Genotype-Tissue Expression (GTEx). Commonfund.nih.gov. Retrieved 25 May 2015, from http://commonfund.nih.gov/GTEx/index

 

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The Clinical Trials 3

Dissertation & Thesis

seo-automated-link-building-1Your dissertation project plays a crucial in your academic career. Essayfreelancewriters.com is ready to help you achieve your career goals. We have thousands writers to provide you with the best dissertations that you need.  Our writers are available to help you complete any dissertation you need including introduction chapter; abstract; literature review; methodology; results; and discussion. In order to complete Master’s degree program, one must present a definitive thesis. We out this into consideration and thus, work hard to ensure that you receive the best thesis that meets your requirements.

 

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Dissertation & Thesis 4